Effect of chemical modulation of toll-like receptor 4 in an animal model of ulcerative colitis.

Facchini, Fabio Alessandro; Di Fusco, Davide; Barresi, Simona; Luraghi, Andrea; Minotti, Alberto; Granucci, Francesca; Monteleone, Giovanni; Peri, Francesco; Monteleone, Ivan

Facchini, Fabio Alessandro; Di Fusco, Davide; Barresi, Simona; Luraghi, Andrea; Minotti, Alberto; Granucci, Francesca; Monteleone, Giovanni; Peri, Francesco; Monteleone, Ivan.

Affiliation

Facchini FA; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milan, Italy.
Di Fusco D; Department of Systems Medicine, University of "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.
Barresi S; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milan, Italy.
Luraghi A; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milan, Italy.
Minotti A; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milan, Italy.
Granucci F; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milan, Italy.
Monteleone G; Department of Systems Medicine, University of "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.
Peri F; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milan, Italy. francesco.peri@unimib.it.
Monteleone I; Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy. ivan.monteleone@uniroma2.it.

Eur J Clin Pharmacol ; 76(3): 409-418, 2020 Mar.

Article in En | MEDLINE | ID: mdl-31982922

Subject(s)

Colitis, Ulcerative/drug therapy; Glycolipids/therapeutic use; Toll-Like Receptor 4/metabolism; Adult; Animals; Cells, Cultured; Colitis, Ulcerative/metabolism; Colon/drug effects; Colon/metabolism; Cytokines/metabolism; Disease Models, Animal; Female; Humans; Inflammation/drug therapy; Inflammation/metabolism; Inflammatory Bowel Diseases/drug therapy; Inflammatory Bowel Diseases/metabolism; Intestinal Mucosa/drug effects; Intestinal Mucosa/metabolism; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/metabolism; Male; Mice; Middle Aged; Young Adult

Key words

Crohn disease; Inflammatory bowel disease (IBD); Lipopolysaccharide (LPS); Synthetic small molecules; Toll-like receptor 4 (TLR4); Ulcerative colitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycolipids / Colitis, Ulcerative / Toll-Like Receptor 4 Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Eur J Clin Pharmacol Year: 2020 Type: Article Affiliation country: Italy

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