A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.
J Antibiot (Tokyo)
; 41(11): 1575-9, 1988 Nov.
Article
in En
| MEDLINE
| ID: mdl-3198491
ABSTRACT
Strain C-1027, an actinomycete isolated from a soil sample collected in China, was found to produce the new antibiotic, C-1027. From taxonomical studies on its morphological, cultural and physiological characteristics, this antibiotic-producing strain was identified as Streptomyces globisporus C-1027. Antibiotic C-1027 has antimicrobial activity against most Gram-positive bacteria but not against Mycobacterium sp. or Gram-negative bacteria. This antibiotic shows remarkable activity in spermatogonial assay and potent cytotoxicity against KB carcinoma cells in vitro, and exhibits inhibition on transplantable tumors in mice.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptomyces
/
Aminoglycosides
/
Anti-Bacterial Agents
/
Antibiotics, Antineoplastic
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Antibiot (Tokyo)
Year:
1988
Type:
Article