Myelin-associated glycoprotein inhibits neurite outgrowth through inactivation of the small GTPase Rap1.
FEBS Lett
; 594(9): 1389-1402, 2020 05.
Article
in En
| MEDLINE
| ID: mdl-31985825
ABSTRACT
Rap1 is a small GTPase that has been implicated in dendritic development and plasticity. In this study, we investigated the role of Rap1 in axonal growth and its activation in response to neurotrophins and myelin-associated inhibitors. We report that Rap1 is activated by brain-derived neurotrophic factor and that this activation can be blocked by myelin-associated glycoprotein (MAG) or central nervous system myelin, which also induced increases in Rap1GAP1 levels. In addition, we demonstrate that adenoviral overexpression of Rap1 enhances neurite outgrowth in the presence of MAG and myelin, while inhibition of Rap1 activity through overexpression of Rap1GAP1 blocks neurite outgrowth. These findings suggest that Rap1GAP1 negatively regulates neurite outgrowth, making it a potential therapeutic target to promote axonal regeneration.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myelin-Associated Glycoprotein
/
Neuronal Outgrowth
/
GTP Phosphohydrolases
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
2020
Type:
Article
Affiliation country:
United States