Antisense oligonucleotides targeting <i>Notch2</i> ameliorate the osteopenic phenotype in a mouse model of Hajdu-Cheney syndrome.

Canalis, Ernesto; Grossman, Tamar R; Carrer, Michele; Schilling, Lauren; Yu, Jungeun

Antisense oligonucleotides targeting Notch2 ameliorate the osteopenic phenotype in a mouse model of Hajdu-Cheney syndrome.

Canalis, Ernesto; Grossman, Tamar R; Carrer, Michele; Schilling, Lauren; Yu, Jungeun.

Affiliation

Canalis E; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030 canalis@uchc.edu.
Grossman TR; Department of Medicine, UConn Health, Farmington, Connecticut 06030.
Carrer M; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.
Schilling L; Ionis Pharmaceuticals, Inc., Carlsbad, California 92010.
Yu J; Ionis Pharmaceuticals, Inc., Carlsbad, California 92010.

J Biol Chem ; 295(12): 3952-3964, 2020 03 20.

Article in En | MEDLINE | ID: mdl-31992595

Subject(s)

Hajdu-Cheney Syndrome/pathology; Oligonucleotides, Antisense/metabolism; Receptor, Notch2/metabolism; Animals; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Bone and Bones/diagnostic imaging; Bone and Bones/pathology; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Disease Models, Animal; Female; Hajdu-Cheney Syndrome/metabolism; Macrophages/cytology; Macrophages/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal/metabolism; Oligonucleotides, Antisense/administration & dosage; Osteoclasts/cytology; Osteoclasts/metabolism; Osteogenesis; Phenotype; Point Mutation; RANK Ligand/genetics; RANK Ligand/metabolism; Receptor, Notch2/antagonists & inhibitors; Receptor, Notch2/genetics

Key words

Hajdu-Cheney syndrome; Notch receptor; antisense oligonucleotides; bone; bone resorption; cell fate; cell signaling; osteoclast; osteoclastogenesis; osteoporosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides, Antisense / Hajdu-Cheney Syndrome / Receptor, Notch2 Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2020 Type: Article

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