Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression.
Science
; 242(4885): 1575-8, 1988 Dec 16.
Article
in En
| MEDLINE
| ID: mdl-3201248
ABSTRACT
Fibroblasts were genetically modified to secrete nerve growth factor (NGF) by infection with a retroviral vector and then implanted into the brains of rats that had surgical lesions of the fimbria-fornix. The grafted cells survived and produced sufficient NGF to prevent the degeneration of cholinergic neurons that would die without treatment. In addition, the protected cholinergic cells sprouted axons that projected in the direction of the cellular source of NGF. These results indicate that a combination of gene transfer and intracerebral grafting may provide an effective treatment for some disorders of the central nervous system.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Fibroblasts
/
Nerve Growth Factors
Limits:
Animals
Language:
En
Journal:
Science
Year:
1988
Type:
Article