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Comparative Molecular Life History of Spontaneous Canine and Human Gliomas.
Amin, Samirkumar B; Anderson, Kevin J; Boudreau, C Elizabeth; Martinez-Ledesma, Emmanuel; Kocakavuk, Emre; Johnson, Kevin C; Barthel, Floris P; Varn, Frederick S; Kassab, Cynthia; Ling, Xiaoyang; Kim, Hoon; Barter, Mary; Lau, Ching C; Ngan, Chew Yee; Chapman, Margaret; Koehler, Jennifer W; Long, James P; Miller, Andrew D; Miller, C Ryan; Porter, Brian F; Rissi, Daniel R; Mazcko, Christina; LeBlanc, Amy K; Dickinson, Peter J; Packer, Rebecca A; Taylor, Amanda R; Rossmeisl, John H; Woolard, Kevin D; Heimberger, Amy B; Levine, Jonathan M; Verhaak, Roel G W.
Affiliation
  • Amin SB; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Anderson KJ; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Boudreau CE; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
  • Martinez-Ledesma E; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenue Morones Prieto 3000, Monterrey, Nuevo Leon 64710, Mexico; Department of Neuro-Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kocakavuk E; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; DKFZ Division of Translational Neurooncology at the West German Cancer Center (WTZ), German Cancer Consortium (DKTK) Partner Site & Department of Neurosurgery, University Hospital Essen, Essen, Germany.
  • Johnson KC; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Barthel FP; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Varn FS; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Kassab C; Department of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Ling X; Department of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kim H; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Barter M; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • Lau CC; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Connecticut Children's Medical Center, Hartford, CT 06106, USA; University of Connecticut School of Medicine, Farmington, CT 06032, USA.
  • Ngan CY; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Chapman M; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Koehler JW; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
  • Long JP; Department of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Miller AD; Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Miller CR; Departments of Pathology and Laboratory Medicine, Neurology, and Pharmacology, Lineberger Comprehensive Cancer Center and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Porter BF; Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
  • Rissi DR; Department of Pathology and Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
  • Mazcko C; Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • LeBlanc AK; Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Dickinson PJ; Department of Surgical and Radiological Sciences, UC Davis School of Veterinary Medicine, Davis, CA, USA.
  • Packer RA; Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
  • Taylor AR; Auburn University College of Veterinary Medicine, Auburn, AL, USA.
  • Rossmeisl JH; VA-MD College of Veterinary Medicine, Blacksburg, VA, USA.
  • Woolard KD; Department of Surgical and Radiological Sciences, UC Davis School of Veterinary Medicine, Davis, CA, USA.
  • Heimberger AB; Department of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Levine JM; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
  • Verhaak RGW; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Electronic address: roel.verhaak@jax.org.
Cancer Cell ; 37(2): 243-257.e7, 2020 02 10.
Article in En | MEDLINE | ID: mdl-32049048
ABSTRACT
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns. Our cross-species comparative genomic analysis provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / DNA Methylation / Glioma / Mutation Limits: Animals / Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2020 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / DNA Methylation / Glioma / Mutation Limits: Animals / Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2020 Type: Article Affiliation country: United States