Autism Spectrum Disorder as a Brain-Gut-Microbiome Axis Disorder.
Dig Dis Sci
; 65(3): 818-828, 2020 03.
Article
in En
| MEDLINE
| ID: mdl-32056091
ABSTRACT
While there are numerous medical comorbidities associated with ASD, gastrointestinal (GI) issues have a significant impact on quality of life for these individuals. Recent findings continue to support the relationship between the gut microbiome and both GI symptoms and behavior, but the heterogeneity within the autism spectrum requires in-depth clinical characterization of these clinical cohorts. Large, diverse, well-controlled studies in this area of research are still needed. Although there is still much to discover about the brain-gut-microbiome axis in ASD, microbially mediated therapies, specifically probiotics and fecal microbiota transplantation have shown promise in the treatment of GI symptoms in ASD, with potential benefit to the core behavioral symptoms of ASD as well. Future research and clinical trials must increasingly consider complex phenotypes in ASD in stratification of large datasets as well as in design of inclusion criteria for individual therapeutic interventions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Gastrointestinal Tract
/
Autism Spectrum Disorder
/
Gastrointestinal Microbiome
/
Gastrointestinal Diseases
Limits:
Animals
/
Humans
Language:
En
Journal:
Dig Dis Sci
Year:
2020
Type:
Article
Affiliation country:
United States