Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Na<sub>v</sub>1.5.

Amarouch, Mohamed-Yassine; Kurt, Han; Delemotte, Lucie; Abriel, Hugues

Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Na_v1.5.

Amarouch, Mohamed-Yassine; Kurt, Han; Delemotte, Lucie; Abriel, Hugues.

Affiliation

Amarouch MY; R.N.E Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohamed Ben Abdellah of Fez, Fez 30000, Morocco.
Kurt H; Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, SE100 44 Solna, Sweden.
Delemotte L; Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, SE100 44 Solna, Sweden.
Abriel H; Institute of Biochemistry and Molecular Medicine (IBMM), University of Bern, 3012 Bern, Switzerland.

Molecules ; 25(4)2020 Feb 18.

Article in En | MEDLINE | ID: mdl-32085432

Subject(s)

Biophysical Phenomena; Catechin/analogs & derivatives; Myocardium/metabolism; NAV1.5 Voltage-Gated Sodium Channel/metabolism; Catechin/chemistry; Catechin/pharmacology; Cell Line; Cell Membrane Permeability/drug effects; Humans; Ion Channel Gating/drug effects; Kinetics; Molecular Dynamics Simulation; Sodium Channel Blockers/pharmacology

Key words

EGCG; Nav1.5; cellular electrophysiology; ion channels; molecular dynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechin / Biophysical Phenomena / NAV1.5 Voltage-Gated Sodium Channel / Myocardium Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: Morocco

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