BAP1-inactivated melanocytic tumor with preserved BAP1 expression? Morphology to the rescue!

Duncan, Lyn M; Tetzlaff, Michael T

Duncan, Lyn M; Tetzlaff, Michael T.

Affiliation

Duncan LM; Dermatopathology Unit, Pathology Service, Massachusetts General Hospital, Boston, Massachusetts.
Tetzlaff MT; Harvard Medical School, Boston, Massachusetts.

J Cutan Pathol ; 47(5): 459-461, 2020 May.

Article in En | MEDLINE | ID: mdl-32096236

ABSTRACT

ABSTRACT

BAP1-inactivated melanocytic tumors typically present with distinctive histopathological changes and loss of nuclear BAP1 protein expression. Rare cases exhibit the typical morphology but with preserved expression of BAP1. In the current issue of Journal of Cutaneous Pathology, Linos et al. describe such a case and provide a comprehensive molecular-genetic exploration to explain such a phenomenon.

Subject(s)

Melanocytes/pathology; Nevus, Epithelioid and Spindle Cell/metabolism; Nevus, Pigmented/genetics; Tumor Suppressor Proteins/metabolism; Ubiquitin Thiolesterase/metabolism; Germ-Line Mutation/genetics; Humans; Immunohistochemistry/methods; Melanocytes/metabolism; Melanocytes/ultrastructure; Mutation, Missense/genetics; Nevus, Epithelioid and Spindle Cell/pathology; Nevus, Pigmented/pathology; Proto-Oncogene Proteins B-raf/metabolism; Skin Neoplasms/pathology

Key words

BAP1; BAP1-inactivated melanocytic nevus; BIMT

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nevus, Epithelioid and Spindle Cell / Tumor Suppressor Proteins / Ubiquitin Thiolesterase / Melanocytes / Nevus, Pigmented Limits: Humans Language: En Journal: J Cutan Pathol Year: 2020 Type: Article

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