Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases.

Kochar, Bharati; Cai, Winston; Cagan, Andrew; Ananthakrishnan, Ashwin N

Kochar, Bharati; Cai, Winston; Cagan, Andrew; Ananthakrishnan, Ashwin N.

Affiliation

Kochar B; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Clinical Translational Epidemiology Unit, The Mongan Institute, Boston, Massachusetts.
Cai W; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.
Cagan A; Partners Healthcare, Boston, Massachusetts.
Ananthakrishnan AN; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Clinical Translational Epidemiology Unit, The Mongan Institute, Boston, Massachusetts. Electronic address: aananthakrishnan@mgh.harvard.edu.

Gastroenterology ; 158(8): 2104-2111.e2, 2020 06.

Article in En | MEDLINE | ID: mdl-32105728

Subject(s)

Colitis, Ulcerative/drug therapy; Crohn Disease/drug therapy; Frailty/complications; Immunocompromised Host; Immunosuppressive Agents/adverse effects; Opportunistic Infections/etiology; Tumor Necrosis Factor Inhibitors/adverse effects; Adult; Age Factors; Colitis, Ulcerative/complications; Colitis, Ulcerative/diagnosis; Colitis, Ulcerative/immunology; Comorbidity; Crohn Disease/complications; Crohn Disease/diagnosis; Crohn Disease/immunology; Female; Frailty/diagnosis; Health Status; Humans; Male; Middle Aged; Opportunistic Infections/diagnosis; Opportunistic Infections/immunology; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome

Key words

Aging; Immunosuppression; Side Effect; Thiopurine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Opportunistic Infections / Colitis, Ulcerative / Crohn Disease / Immunocompromised Host / Frailty / Tumor Necrosis Factor Inhibitors / Immunosuppressive Agents Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Gastroenterology Year: 2020 Type: Article

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