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Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation.
Liddle, John; Hutchinson, Jonathan P; Kitchen, Semra; Rowland, Paul; Neu, Margarete; Cecconie, Ted; Holmes, Duncan S; Jones, Emma; Korczynska, Justyna; Koumantou, Despoina; Lea, Jonathan D; Nickels, Leng; Pemberton, Michelle; Phillipou, Alex; Schneck, Jessica L; Sheehan, Hester; Tinworth, Christopher P; Uings, Iain; Wojno-Picon, Justyna; Young, Robert J; Stratikos, Efstratios.
Affiliation
  • Liddle J; Discovery Partnerships with Academia, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Hutchinson JP; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Kitchen S; Discovery Partnerships with Academia, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Rowland P; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Neu M; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Cecconie T; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States.
  • Holmes DS; Discovery Partnerships with Academia, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Jones E; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Korczynska J; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Koumantou D; National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou and Neapoleos 27, Agia Paraskevi, Athens 15341, Greece.
  • Lea JD; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Nickels L; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States.
  • Pemberton M; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Phillipou A; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Schneck JL; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States.
  • Sheehan H; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Tinworth CP; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Uings I; Discovery Partnerships with Academia, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Wojno-Picon J; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Young RJ; Medicinal Science and Technology, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Stratikos E; National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou and Neapoleos 27, Agia Paraskevi, Athens 15341, Greece.
J Med Chem ; 63(6): 3348-3358, 2020 03 26.
Article in En | MEDLINE | ID: mdl-32109056
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Protease Inhibitors / Antigen Presentation / Diterpenes, Clerodane / Aminopeptidases / Epitopes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Protease Inhibitors / Antigen Presentation / Diterpenes, Clerodane / Aminopeptidases / Epitopes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Type: Article Affiliation country: United kingdom