Consumption of a diet high in dairy leads to higher 15:0 in cholesteryl esters of healthy people when compared to diets high in meat and grain.
Nutr Metab Cardiovasc Dis
; 30(5): 804-809, 2020 05 07.
Article
in En
| MEDLINE
| ID: mdl-32139254
ABSTRACT
BACKGROUND AND AIMS:
A higher dairy product intake has been associated to higher blood concentrations of 150 (pentadecanoic acid), 170 (margaric acid), and 140 (myristic acid). This study investigates whether a diet high in dairy products influences cholesteryl ester fatty acid concentrations of these specific fatty acids (FA). METHODS ANDRESULTS:
In a randomized multiple cross-over study, 13 men and 17 women aged 22 ± 4 years with a BMI of 21.6 ± 2.2 kg/m2 received 3 isocaloric intervention diets (dairy, meat or grain) in random order. For this post-hoc analysis, FA in plasma cholesteryl esters were measured using gas chromatography. We performed a linear mixed model per centered log-ratio transformed FA, adjusting for period, and the interaction between diet and period. Consumed total fat intake per controlled intervention diet was 31.0 ± 0.9 en%/day (dairy), 31.5 ± 0.6 en%/day (meat), and 28.4 ± 1.2 en%/day (grain), respectively. The dairy diet led to higher relative concentrations of 150 when compared to diets high in meat and grain, (ß; 0.27, 95%CI 0.18,0.37; p = 1.2 × 10-5, and ß 0.15; 95%CI 0.06,0.24; p = 1.2 × 10-2, respectively). The dairy diet also led to higher 140 when compared to the meat diet (ß 0.34; 95%CI 0.21,0.46; p = 6.0 × 10-5), but not when compared to the grain diet. 170 did not differ between diets.CONCLUSION:
The plasma cholesteryl ester fraction after a diet high in dairy was characterized by higher 150 levels. Concentrations of 140 were only higher when comparing the FA profile after a diet high in dairy when compared to a diet high in meat. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov, NCT01314040.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Edible Grain
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Cholesterol Esters
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Dairy Products
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Diet
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Fatty Acids
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Feeding Behavior
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Meat
Type of study:
Clinical_trials
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
Country/Region as subject:
Europa
Language:
En
Journal:
Nutr Metab Cardiovasc Dis
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
/
METABOLISMO
Year:
2020
Type:
Article