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Hydrophobic substituents on isatin derivatives enhance their inhibition against bacterial peptidoglycan glycosyltransferase activity.
Wang, Yong; Cheong, Wing-Lam; Liang, Zhiguang; So, Lok-Yan; Chan, Kin-Fai; So, Pui-Kin; Chen, Yu Wai; Wong, Wing-Leung; Wong, Kwok-Yin.
Affiliation
  • Wang Y; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China.
  • Cheong WL; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China.
  • Liang Z; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China.
  • So LY; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China.
  • Chan KF; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China.
  • So PK; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China.
  • Chen YW; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China.
  • Wong WL; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China.
  • Wong KY; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China. Electronic address: kwok-yin.wong@polyu.edu.hk.
Bioorg Chem ; 97: 103710, 2020 04.
Article in En | MEDLINE | ID: mdl-32146179
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / Peptidoglycan Glycosyltransferase / Isatin / Anti-Bacterial Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / Peptidoglycan Glycosyltransferase / Isatin / Anti-Bacterial Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2020 Type: Article Affiliation country: China