Loss of RBBP4 results in defective inner cell mass, severe apoptosis, hyperacetylated histones and preimplantation lethality in mice.

Miao, Xiaosu; Sun, Tieqi; Barletta, Holly; Mager, Jesse; Cui, Wei

Loss of RBBP4 results in defective inner cell mass, severe apoptosis, hyperacetylated histones and preimplantation lethality in mice.

Miao, Xiaosu; Sun, Tieqi; Barletta, Holly; Mager, Jesse; Cui, Wei.

Affiliation

Miao X; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Sun T; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Barletta H; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Mager J; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Cui W; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.

Biol Reprod ; 103(1): 13-23, 2020 06 23.

Article in En | MEDLINE | ID: mdl-32285100

Subject(s)

Apoptosis; Blastocyst/physiology; Embryo Loss; Endoderm/embryology; Histones/metabolism; Retinoblastoma-Binding Protein 4/physiology; Acetylation; Animals; Embryo Implantation/physiology; Embryonic Development/physiology; Endoderm/cytology; Female; Gene Expression; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Retinoblastoma-Binding Protein 4/deficiency; Retinoblastoma-Binding Protein 4/genetics

Key words

DNA damage; blastocyst embryo; cell lineage specification; histone acetylation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blastocyst / Histones / Apoptosis / Embryo Loss / Endoderm / Retinoblastoma-Binding Protein 4 Limits: Animals Language: En Journal: Biol Reprod Year: 2020 Type: Article Affiliation country: United States

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