Deep DNA metagenomic sequencing reveals oral microbiome divergence between monozygotic twins discordant for multiple sclerosis severity.
J Neuroimmunol
; 343: 577237, 2020 06 15.
Article
in En
| MEDLINE
| ID: mdl-32289594
ABSTRACT
In contrast to gut, the oral microbiome of MS patients has not been characterized. Deep sequencing of saliva DNA from a pair of monozygotic twins (MSF1 with relapsing remitting MS; MSF2 with clinically isolated syndrome) identified 2036 bacterial species. Relative abundances of 3 phyla were higher, and 3 lower in MSF1 versus MSF2. Species diversity was greater in MSF2, and 20 abundant species differed at least 2-fold. Pathway analysis identified 116 functional hierarchies differing 50% or more. Although limited to one pair of twins, our data suggests that oral microbiome analysis may be useful for diagnosis or monitoring therapeutic efficacy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Demyelinating Diseases
/
Multiple Sclerosis, Relapsing-Remitting
/
Mouth
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
J Neuroimmunol
Year:
2020
Type:
Article