<i>Gentiana lutea</i> Extract Modulates Ceramide Synthesis in Primary and Psoriasis-Like Keratinocytes.

Gendrisch, Fabian; Novácková, Anna; Sochorová, Michaela; Haarhaus, Birgit; Vávrová, Katerina; Schempp, Christoph M; Wölfle, Ute

Gentiana lutea Extract Modulates Ceramide Synthesis in Primary and Psoriasis-Like Keratinocytes.

Gendrisch, Fabian; Novácková, Anna; Sochorová, Michaela; Haarhaus, Birgit; Vávrová, Katerina; Schempp, Christoph M; Wölfle, Ute.

Affiliation

Gendrisch F; Department of Dermatology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Breisgau, Germany.
Novácková A; Skin Barrier Research Group, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, CZ-50005 Hradec Králové, Czech Republic.
Sochorová M; Skin Barrier Research Group, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, CZ-50005 Hradec Králové, Czech Republic.
Haarhaus B; Department of Dermatology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Breisgau, Germany.
Vávrová K; Skin Barrier Research Group, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, CZ-50005 Hradec Králové, Czech Republic.
Schempp CM; Department of Dermatology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Breisgau, Germany.
Wölfle U; Department of Dermatology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Breisgau, Germany.

Molecules ; 25(8)2020 Apr 16.

Article in En | MEDLINE | ID: mdl-32316273

Subject(s)

Ceramides/metabolism; Gentiana/chemistry; Keratinocytes/cytology; Plant Extracts/pharmacology; Psoriasis/metabolism; Case-Control Studies; Cells, Cultured; Eye Proteins/genetics; Eye Proteins/metabolism; Fatty Acid Elongases/genetics; Fatty Acid Elongases/metabolism; Gene Expression Regulation/drug effects; Humans; Keratinocytes/drug effects; Keratinocytes/metabolism; Lipid Metabolism/drug effects; Membrane Proteins/genetics; Membrane Proteins/metabolism; Plant Extracts/chemistry; Primary Cell Culture; Psoriasis/genetics; Sphingosine N-Acyltransferase/genetics; Sphingosine N-Acyltransferase/metabolism

Key words

CerS; ELOVL; Gentiana lutea; ceramides; skin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Plant Extracts / Keratinocytes / Ceramides / Gentiana Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: Germany

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