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A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex.
Wu, Tian-Ying; Huang, Qiong; Huang, Zhi-Shu; Hu, Ming-Hao; Tan, Jia-Heng.
Affiliation
  • Wu TY; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
  • Huang Q; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China.
  • Huang ZS; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
  • Hu MH; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China. Electronic address: 642469829@qq.com.
  • Tan JH; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: tanjiah@mail.sysu.edu.cn.
Bioorg Chem ; 99: 103866, 2020 06.
Article in En | MEDLINE | ID: mdl-32330737
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-myc / Benzothiazoles / G-Quadruplexes / Imidazoles / Melanoma / Antineoplastic Agents Limits: Animals Language: En Journal: Bioorg Chem Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-myc / Benzothiazoles / G-Quadruplexes / Imidazoles / Melanoma / Antineoplastic Agents Limits: Animals Language: En Journal: Bioorg Chem Year: 2020 Type: Article Affiliation country: China