Short- and long-term mortality following hypnotic use.
J Sleep Res
; 29(4): e13061, 2020 08.
Article
in En
| MEDLINE
| ID: mdl-32420667
ABSTRACT
Potential long-term consequences of hypnotics remain controversial. We used the prospective Swedish National March Cohort, a study based on 41,695 participants with a mean follow-up duration of 18.9 years. Logistic regression models and Cox proportional hazards models with attained age as timescale were used to assess associations of hypnotic use with short- and long-term mortality. The proportion of subjects who initiated or discontinued hypnotic use during follow-up was substantial. All groups of hypnotics were associated with increased mortality within 2 years after a first prescription, with an overall OR of 2.38 (95% CI, 2.13-2.66). The association was more pronounced among subjects younger than 60 years (OR, 6.16; 95% CI, 3.98-9.52). There was no association between hypnotic use and long-term mortality. The association between hypnotic use and increased mortality was thus restricted to a relatively short period after treatment initiation, and may be explained in terms of confounding by indication.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hypnotics and Sedatives
/
Sleep Initiation and Maintenance Disorders
Limits:
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Sleep Res
Journal subject:
PSICOFISIOLOGIA
Year:
2020
Type:
Article
Affiliation country:
Sweden