PD-L1 expression correlates with tumor-infiltrating lymphocytes and better prognosis in patients with HPV-negative head and neck squamous cell carcinomas.

Sanchez-Canteli, Mario; Granda-Díaz, Rocio; Del Rio-Ibisate, Nagore; Allonca, Eva; López-Alvarez, Fernando; Agorreta, Jackeline; Garmendia, Irati; Montuenga, Luis M; García-Pedrero, Juana M; Rodrigo, Juan P

Sanchez-Canteli, Mario; Granda-Díaz, Rocio; Del Rio-Ibisate, Nagore; Allonca, Eva; López-Alvarez, Fernando; Agorreta, Jackeline; Garmendia, Irati; Montuenga, Luis M; García-Pedrero, Juana M; Rodrigo, Juan P.

Affiliation

Sanchez-Canteli M; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, 33011, Oviedo, Spain.
Granda-Díaz R; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, 33011, Oviedo, Spain.
Del Rio-Ibisate N; Ciber de Cáncer, CIBERONC, 28029, Madrid, Spain.
Allonca E; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, 33011, Oviedo, Spain.
López-Alvarez F; Ciber de Cáncer, CIBERONC, 28029, Madrid, Spain.
Agorreta J; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, 33011, Oviedo, Spain.
Garmendia I; Ciber de Cáncer, CIBERONC, 28029, Madrid, Spain.
Montuenga LM; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, 33011, Oviedo, Spain.
García-Pedrero JM; Ciber de Cáncer, CIBERONC, 28029, Madrid, Spain.
Rodrigo JP; Ciber de Cáncer, CIBERONC, 28029, Madrid, Spain.

Cancer Immunol Immunother ; 69(10): 2089-2100, 2020 Oct.

Article in En | MEDLINE | ID: mdl-32448984

Subject(s)

B7-H1 Antigen/metabolism; Head and Neck Neoplasms/immunology; Lymphocytes, Tumor-Infiltrating/immunology; Papillomaviridae/immunology; Papillomavirus Infections/complications; Squamous Cell Carcinoma of Head and Neck/immunology; Tumor Microenvironment/immunology; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor/metabolism; Female; Follow-Up Studies; Head and Neck Neoplasms/metabolism; Head and Neck Neoplasms/pathology; Head and Neck Neoplasms/virology; Humans; Male; Middle Aged; Papillomavirus Infections/immunology; Papillomavirus Infections/virology; Prognosis; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck/metabolism; Squamous Cell Carcinoma of Head and Neck/pathology; Squamous Cell Carcinoma of Head and Neck/virology; Survival Rate

Key words

Head and neck cancer; PD-L1; Prognosis; Tumor-infiltrating lymphocytes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Papillomaviridae / Lymphocytes, Tumor-Infiltrating / Papillomavirus Infections / Tumor Microenvironment / B7-H1 Antigen / Squamous Cell Carcinoma of Head and Neck / Head and Neck Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Immunol Immunother Journal subject: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Year: 2020 Type: Article Affiliation country: Spain

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