[New Therapeutic Options for the Individualised Titration of Levodopa]. / Neue Therapieoption zur individualisierten Titration von Levodopa.
Fortschr Neurol Psychiatr
; 89(1-02): 23-28, 2021 Jan.
Article
in De
| MEDLINE
| ID: mdl-32462651
ABSTRACT
Levodopa is the most effective medication in the treatment of Parkinson's disease. In the course of the disease the storage facility of dopaminergic neurones deteriorates, so that the duration of the half-life period likewise converges. This results in fluctuations in performance, and also in dyskinesias as a further consequence of the narrowing therapeutic window. Therapeutically, this in turn leads to further fractioning of the levodopa dosage and a reduction of single-dose levels. There is, however, only limited scope for doing this with the conventional levodopa formulations. For this reason, the introduction of water-soluble microtablets à 5â/â1.25âmg levodopaâ/âcarbidopa can be regarded as a beneficial extension permitting for fine titration of the dopaminergic stimulation. Here we present this new therapeutic principle, the available data and concepts for clinical use.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Dyskinesias
Limits:
Humans
Language:
De
Journal:
Fortschr Neurol Psychiatr
Year:
2021
Type:
Article