Serum Metabolome Changes in Relation to Prothrombotic State Induced by Combined Oral Contraceptives with Drospirenone and Ethinylestradiol.

Swanepoel, Albe Carina; Bester, Janette; Emmerson, Odette; Soma, Prashilla; Beukes, Derylize; van Reenen, Mari; Loots, Du Toit; du Preez, Ilse

Swanepoel, Albe Carina; Bester, Janette; Emmerson, Odette; Soma, Prashilla; Beukes, Derylize; van Reenen, Mari; Loots, Du Toit; du Preez, Ilse.

Affiliation

Swanepoel AC; Department of Physiology and Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Bester J; Department of Physiology and Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Emmerson O; Department of Physiology and Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Soma P; Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Beukes D; Human Metabolomics, North-West University, Potchefstroom, South Africa.
van Reenen M; Human Metabolomics, North-West University, Potchefstroom, South Africa.
Loots DT; Human Metabolomics, North-West University, Potchefstroom, South Africa.
du Preez I; Human Metabolomics, North-West University, Potchefstroom, South Africa.

OMICS ; 24(7): 404-414, 2020 07.

Article in En | MEDLINE | ID: mdl-32471328

Subject(s)

Androstenes/adverse effects; Biomarkers/blood; Blood Coagulation/drug effects; Contraceptives, Oral, Combined/adverse effects; Ethinyl Estradiol/adverse effects; Metabolome; Adolescent; Adult; Androstenes/administration & dosage; Blood Platelets/drug effects; Blood Platelets/metabolism; Blood Platelets/ultrastructure; Contraceptives, Oral, Combined/administration & dosage; Erythrocytes/drug effects; Erythrocytes/metabolism; Erythrocytes/ultrastructure; Ethinyl Estradiol/administration & dosage; Female; Gas Chromatography-Mass Spectrometry; Humans; Metabolomics/methods; Platelet Activation/drug effects; Platelet Aggregation/drug effects; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thrombosis/blood; Thrombosis/diagnosis; Thrombosis/etiology; Young Adult

Key words

combined oral contraceptives; drospirenone; ethinylestradiol; metabolomics; serum

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Coagulation / Biomarkers / Contraceptives, Oral, Combined / Ethinyl Estradiol / Metabolome / Androstenes Type of study: Diagnostic_studies / Etiology_studies Limits: Adolescent / Adult / Female / Humans Language: En Journal: OMICS Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: South Africa

Fulltext

XML

PubMed Links

Search on Google