Neuroprotection of melatonin on spinal cord injury by activating autophagy and inhibiting apoptosis via SIRT1/AMPK signaling pathway.

Gao, Kai; Niu, Jianbing; Dang, Xiaoqian

Gao, Kai; Niu, Jianbing; Dang, Xiaoqian.

Affiliation

Gao K; Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, China.
Niu J; Department of Orthopedics, Jining No.1 People's Hospital, Jining, China.
Dang X; Department of Orthopedics, Jining No.1 People's Hospital, Jining, China.

Biotechnol Lett ; 42(10): 2059-2069, 2020 Oct.

Article in En | MEDLINE | ID: mdl-32514788

Subject(s)

Apoptosis/drug effects; Autophagy/drug effects; Melatonin/pharmacology; Neuroprotective Agents/pharmacology; Spinal Cord Injuries/metabolism; AMP-Activated Protein Kinases/metabolism; Animals; Male; Rats; Rats, Sprague-Dawley; Signal Transduction/drug effects; Sirtuin 1/metabolism; Spinal Cord/cytology; Spinal Cord/drug effects

Key words

Apoptosis; Autophagy; Melatonin; SIRT1/AMPK signaling pathway; Spinal cord injury

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Autophagy / Apoptosis / Neuroprotective Agents / Melatonin Limits: Animals Language: En Journal: Biotechnol Lett Year: 2020 Type: Article Affiliation country: China

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