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Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.
Jimenez-Vargas, Nestor N; Gong, Jing; Wisdom, Matthew J; Jensen, Dane D; Latorre, Rocco; Hegron, Alan; Teng, Shavonne; DiCello, Jesse J; Rajasekhar, Pradeep; Veldhuis, Nicholas A; Carbone, Simona E; Yu, Yang; Lopez-Lopez, Cintya; Jaramillo-Polanco, Josue; Canals, Meritxell; Reed, David E; Lomax, Alan E; Schmidt, Brian L; Leong, Kam W; Vanner, Stephen J; Halls, Michelle L; Bunnett, Nigel W; Poole, Daniel P.
Affiliation
  • Jimenez-Vargas NN; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
  • Gong J; Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10032.
  • Wisdom MJ; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
  • Jensen DD; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
  • Latorre R; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
  • Hegron A; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
  • Teng S; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
  • DiCello JJ; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
  • Rajasekhar P; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Veldhuis NA; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Carbone SE; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Yu Y; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Lopez-Lopez C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Jaramillo-Polanco J; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
  • Canals M; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
  • Reed DE; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
  • Lomax AE; Centre for Membrane Proteins and Receptors and Division of Physiology, Pharmacology, and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, NG7 2RD Nottingham, United Kingdom.
  • Schmidt BL; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
  • Leong KW; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
  • Vanner SJ; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
  • Halls ML; Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10032.
  • Bunnett NW; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
  • Poole DP; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; michelle.halls@monash.edu nwb2@nyu.edu daniel.poole@monash.edu.
Proc Natl Acad Sci U S A ; 117(26): 15281-15292, 2020 06 30.
Article in En | MEDLINE | ID: mdl-32546520
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Enkephalin, Leucine-2-Alanine / Receptors, Opioid, delta / Inflammation Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Enkephalin, Leucine-2-Alanine / Receptors, Opioid, delta / Inflammation Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article