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Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.
Ladomersky, Erik; Zhai, Lijie; Lauing, Kristen L; Bell, April; Xu, Jiahui; Kocherginsky, Masha; Zhang, Bin; Wu, Jennifer D; Podojil, Joseph R; Platanias, Leonidas C; Mochizuki, Aaron Y; Prins, Robert M; Kumthekar, Priya; Raizer, Jeffrey J; Dixit, Karan; Lukas, Rimas V; Horbinski, Craig; Wei, Min; Zhou, Changyou; Pawelec, Graham; Campisi, Judith; Grohmann, Ursula; Prendergast, George C; Munn, David H; Wainwright, Derek A.
Affiliation
  • Ladomersky E; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Zhai L; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Lauing KL; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Bell A; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Xu J; Department of Preventive Medicine-Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Kocherginsky M; Department of Preventive Medicine-Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Zhang B; Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Wu JD; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Podojil JR; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Platanias LC; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Mochizuki AY; Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Prins RM; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Kumthekar P; Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.
  • Raizer JJ; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, California.
  • Dixit K; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Lukas RV; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Horbinski C; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Wei M; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Zhou C; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Pawelec G; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Campisi J; BeiGene, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, China.
  • Grohmann U; BeiGene, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, China.
  • Prendergast GC; Department of Immunology, University of Tübingen, Tübingen, Germany.
  • Munn DH; Buck Institute for Research on Aging, Novato, California.
  • Wainwright DA; Lawrence Berkeley National Laboratory, Berkeley, California.
Clin Cancer Res ; 26(19): 5232-5245, 2020 10 01.
Article in En | MEDLINE | ID: mdl-32546647
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Glioblastoma / Indoleamine-Pyrrole 2,3,-Dioxygenase / Isocitrate Dehydrogenase Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Glioblastoma / Indoleamine-Pyrrole 2,3,-Dioxygenase / Isocitrate Dehydrogenase Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2020 Type: Article