Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study.

Zamarin, Dmitriy; Hamid, Omid; Nayak-Kapoor, Asha; Sahebjam, Solmaz; Sznol, Mario; Collaku, Agron; Fox, Floyd E; Marshall, Margaret A; Hong, David S

Zamarin, Dmitriy; Hamid, Omid; Nayak-Kapoor, Asha; Sahebjam, Solmaz; Sznol, Mario; Collaku, Agron; Fox, Floyd E; Marshall, Margaret A; Hong, David S.

Affiliation

Zamarin D; Memorial Sloan-Kettering Cancer Center, New York, New York. dshong@mdanderson.org Zamarind@mskcc.org.
Hamid O; The Angeles Clinic and Research Institute, Los Angeles, California.
Nayak-Kapoor A; Georgia Cancer Center, Augusta University, Augusta, Georgia.
Sahebjam S; H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida.
Sznol M; Yale Cancer Center, New Haven, Connecticut.
Collaku A; Kyowa Kirin Pharmaceutical Development, Inc., Princeton, New Jersey.
Fox FE; Kyowa Kirin Pharmaceutical Development, Inc., Princeton, New Jersey.
Marshall MA; Kyowa Kirin Pharmaceutical Development, Inc., Princeton, New Jersey.
Hong DS; MD Anderson Cancer Center, Houston, Texas. dshong@mdanderson.org Zamarind@mskcc.org.

Clin Cancer Res ; 26(17): 4531-4541, 2020 09 01.

Article in En | MEDLINE | ID: mdl-32586937

Subject(s)

Antibodies, Monoclonal, Humanized/administration & dosage; Antineoplastic Agents, Immunological/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Lymphocyte Depletion/methods; Pancreatic Neoplasms/drug therapy; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/adverse effects; Antibodies, Monoclonal, Humanized/adverse effects; Antineoplastic Agents, Immunological/adverse effects; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Dose-Response Relationship, Drug; Female; Humans; Lymphocyte Depletion/adverse effects; Male; Middle Aged; Neoplasm Staging; Pancreatic Neoplasms/blood; Pancreatic Neoplasms/diagnosis; Pancreatic Neoplasms/immunology; Receptors, CCR4/antagonists & inhibitors; Receptors, CCR4/metabolism; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/metabolism; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Lymphocyte Depletion / Antibodies, Monoclonal, Humanized / Antineoplastic Agents, Immunological Type of study: Clinical_trials / Diagnostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2020 Type: Article

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