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Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania.
Medeiros, Andrea; Benítez, Diego; Korn, Ricarda S; Ferreira, Vinicius C; Barrera, Exequiel; Carrión, Federico; Pritsch, Otto; Pantano, Sergio; Kunick, Conrad; de Oliveira, Camila I; Orban, Oliver C F; Comini, Marcelo A.
Affiliation
  • Medeiros A; Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Benítez D; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
  • Korn RS; Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Ferreira VC; Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany.
  • Barrera E; Instituto Gonçalo Moniz (IGM), FIOCRUZ, Salvador, Brazil.
  • Carrión F; Biomolecular Simulations Group, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Pritsch O; Protein Biophysics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Pantano S; Protein Biophysics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Kunick C; Departamento de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
  • de Oliveira CI; Biomolecular Simulations Group, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Orban OCF; Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany.
  • Comini MA; Instituto Gonçalo Moniz (IGM), FIOCRUZ, Salvador, Brazil.
J Enzyme Inhib Med Chem ; 35(1): 1345-1358, 2020 Dec.
Article in En | MEDLINE | ID: mdl-32588679
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzazepines / Spermidine / Glutathione / Leishmania Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article Affiliation country: Uruguay
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzazepines / Spermidine / Glutathione / Leishmania Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article Affiliation country: Uruguay