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Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease.
Karayel, Özge; Tonelli, Francesca; Virreira Winter, Sebastian; Geyer, Phillip E; Fan, Ying; Sammler, Esther M; Alessi, Dario R; Steger, Martin; Mann, Matthias.
Affiliation
  • Karayel Ö; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
  • Tonelli F; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, United Kingdom.
  • Virreira Winter S; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
  • Geyer PE; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
  • Fan Y; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, United Kingdom.
  • Sammler EM; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, United Kingdom; Department of Neurology, School of Medicine, Ninewells Hospital, Ninewells Drive, Dundee, United Kingdom.
  • Alessi DR; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, United Kingdom.
  • Steger M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. Electronic address: martin.steger@evotec.com.
  • Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. Electronic address: mmann@biochem.mpg.de.
Mol Cell Proteomics ; 19(9): 1546-1560, 2020 09.
Article in En | MEDLINE | ID: mdl-32601174
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Rab GTP-Binding Proteins / Proteome / Protein Kinase Inhibitors / Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Neutrophils Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cell Proteomics Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2020 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Rab GTP-Binding Proteins / Proteome / Protein Kinase Inhibitors / Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Neutrophils Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cell Proteomics Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2020 Type: Article Affiliation country: Germany