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A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
Reynaud, Steve; Ciolek, Justyna; Degueldre, Michel; Saez, Natalie J; Sequeira, Ana Filipa; Duhoo, Yoan; Brás, Joana L A; Meudal, Hervé; Cabo Díez, Miguel; Fernández Pedrosa, Victoria; Verdenaud, Marion; Boeri, Julia; Pereira Ramos, Oscar; Ducancel, Frédéric; Vanden Driessche, Margot; Fourmy, Rudy; Violette, Aude; Upert, Grégory; Mourier, Gilles; Beck-Sickinger, Annette G; Mörl, Karin; Landon, Céline; Fontes, Carlos M G A; Miñambres Herráiz, Rebeca; Rodríguez de la Vega, Ricardo C; Peigneur, Steve; Tytgat, Jan; Quinton, Loïc; De Pauw, Edwin; Vincentelli, Renaud; Servent, Denis; Gilles, Nicolas.
Affiliation
  • Reynaud S; Université Paris-Sud, 15 Rue Georges Clemenceau, Orsay 91405 France.
  • Ciolek J; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette 91191 France.
  • Degueldre M; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette 91191 France.
  • Saez NJ; Mass Spectrometry Laboratory, Université de Liège, Allée du six Aout 11, Quartier Agora, Liege 4000 Belgium.
  • Sequeira AF; Department of Analytical Science Biologicals, UCB, Chemin du Foriest, Braine L'Alleud 1420 Belgium.
  • Duhoo Y; Centre National de la Recherche Scientifique, Architecture et Fonction des Macromolécules Biologiques, Campus de Luminy, Marseille 13288 France.
  • Brás JLA; Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, QLD, Australia.
  • Meudal H; Universidade de Lisboa, CIISA - Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, Lisboa 1300-477 Portugal.
  • Cabo Díez M; NZYTech Lda, Genes & Enzymes, Estrada do Paço do Lumiar, Campus do Lumiar, Edifício E - R/C, Lisboa 1649-038 Portugal.
  • Fernández Pedrosa V; Centre National de la Recherche Scientifique, Architecture et Fonction des Macromolécules Biologiques, Campus de Luminy, Marseille 13288 France.
  • Verdenaud M; Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, QLD, Australia.
  • Boeri J; Universidade de Lisboa, CIISA - Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, Lisboa 1300-477 Portugal.
  • Pereira Ramos O; NZYTech Lda, Genes & Enzymes, Estrada do Paço do Lumiar, Campus do Lumiar, Edifício E - R/C, Lisboa 1649-038 Portugal.
  • Ducancel F; Centre National de la Recherche Scientifique, Centre de Biophysique Moléculaire, rue Charles Sadron, Orléans 45071 France.
  • Vanden Driessche M; Next-Generation Sequencing Laboratory, Sistemas Genómicos Ltd., Ronda de Guglielmo Marconi, 6, Paterna 46980 Spain.
  • Fourmy R; Next-Generation Sequencing Laboratory, Sistemas Genómicos Ltd., Ronda de Guglielmo Marconi, 6, Paterna 46980 Spain.
  • Violette A; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette 91191 France.
  • Upert G; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette 91191 France.
  • Mourier G; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette 91191 France.
  • Beck-Sickinger AG; Université Paris Saclay, CEA, Département IDMIT, 18 route du Panorama, 92265 Fontenay-aux-Roses, France.
  • Mörl K; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette 91191 France.
  • Landon C; Alphabiotoxine Laboratory sprl, Barberie 15, Montroeul-au-bois 7911 Belgium.
  • Fontes CMGA; Alphabiotoxine Laboratory sprl, Barberie 15, Montroeul-au-bois 7911 Belgium.
  • Miñambres Herráiz R; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette 91191 France.
  • Rodríguez de la Vega RC; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette 91191 France.
  • Peigneur S; Institute of Biochemistry, Universitat Leipzig, Leipzig 04103 Germany.
  • Tytgat J; Institute of Biochemistry, Universitat Leipzig, Leipzig 04103 Germany.
  • Quinton L; Centre National de la Recherche Scientifique, Centre de Biophysique Moléculaire, rue Charles Sadron, Orléans 45071 France.
  • De Pauw E; Universidade de Lisboa, CIISA - Faculdade de Medicina Veterinária, Avenida da Universidade Técnica, Lisboa 1300-477 Portugal.
  • Vincentelli R; NZYTech Lda, Genes & Enzymes, Estrada do Paço do Lumiar, Campus do Lumiar, Edifício E - R/C, Lisboa 1649-038 Portugal.
  • Servent D; Next-Generation Sequencing Laboratory, Sistemas Genómicos Ltd., Ronda de Guglielmo Marconi, 6, Paterna 46980 Spain.
  • Gilles N; Universite Paris-Sud, Ecologie, Systematique et Evolution, 15 rue Georges Clémenceau, Orsay 91405 France.
J Med Chem ; 63(15): 8250-8264, 2020 08 13.
Article in En | MEDLINE | ID: mdl-32602722
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scorpion Venoms / Proteomics / Receptors, Melanocortin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scorpion Venoms / Proteomics / Receptors, Melanocortin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Type: Article