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Variability of TSNA in U.S. Tobacco and Moist Smokeless Tobacco Products.
Oldham, M J; Lion, K E; Phillips, D J; Morton, M J; Lusso, M F; Harris, E A; Jordan, J L; Franke, J E; Strickland, J A.
Affiliation
  • Oldham MJ; Altria Client Services LLC, United States.
  • Lion KE; Altria Client Services LLC, United States.
  • Phillips DJ; Altria Client Services LLC, United States.
  • Morton MJ; Altria Client Services LLC, United States.
  • Lusso MF; Altria Client Services LLC, United States.
  • Harris EA; U.S. Smokeless Tobacco Company, United States.
  • Jordan JL; U.S. Smokeless Tobacco Company, United States.
  • Franke JE; Altria Client Services LLC, United States.
  • Strickland JA; Altria Client Services LLC, United States.
Toxicol Rep ; 7: 752-758, 2020.
Article in En | MEDLINE | ID: mdl-32612935
ABSTRACT
Tobacco-specific nitrosamines (TSNAs) have been of concern to the public health community for decades and their reduction through agricultural practices, plant breeding, and tobacco processing has also been a decades-long industry effort. Despite those efforts, TSNAs, though lower, continue to be constituents of concern in tobacco products. This paper examines the TSNA levels of dark air-cured, dark fire-cured, and burley tobaccos purchased in the United States by U.S. Smokeless Tobacco Company LLC (USSTC) and of nine finished USSTC moist smokeless tobacco products. TSNA values of the incoming purchased tobaccos and the finished products showed considerable variability. For the incoming tobaccos, the coefficient of variation was generally more than 100 % for each tobacco type and for each of the measured TSNAs. The relative TSNA variability of the finished tobacco products was also considerable, averaging approximately 25 %. It was also found that the measured values for the finished products averaged well above the proposed FDA NNN proposed product standard of 1.0 µg/g dry weight. Because of the large variability in NNN values, products would have to average well below FDA's proposed product standard to be consistently compliant.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Toxicol Rep Year: 2020 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Toxicol Rep Year: 2020 Type: Article Affiliation country: United States