ER-associated Protein Degradation at Atomic Resolution.
Trends Biochem Sci
; 45(9): 723-725, 2020 09.
Article
in En
| MEDLINE
| ID: mdl-32616332
ABSTRACT
The endoplasmic reticulum-associated degradation (ERAD) pathway eliminates misfolded proteins. The Hrd1 complex represents the main gate mediating retrotranslocation of ER luminal misfolded (ERAD-L) substrates to the cytosol. A recent cryo-electron microscopy (cryo-EM) study by Wu et al. unveils the structural features of active Hrd1, providing mechanistic insights into the movement of proteins directed for degradation across ER membranes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cryoelectron Microscopy
/
Endoplasmic Reticulum-Associated Degradation
Type of study:
Risk_factors_studies
Language:
En
Journal:
Trends Biochem Sci
Year:
2020
Type:
Article