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Case Report: Dynamics of Acquired Fluoroquinolone Resistance under Standardized Short-Course Treatment of Multidrug-Resistant Tuberculosis.
Ngabonziza, Jean Claude Semuto; Van Deun, Armand; Migambi, Patrick; Niyigena, Esdras Belamo; Dusabe, Théogène; Habimana, Yves Mucyo; Ushizimpumu, Bertin; Mulders, Wim; Decroo, Tom; Affolabi, Dissou; Supply, Philip; de Jong, Bouke C; Rigouts, Leen.
Affiliation
  • Ngabonziza JCS; 1National Reference Laboratory Division, Department of Biomedical Services, Rwanda Biomedical Centre, Kigali, Rwanda.
  • Van Deun A; 2Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Migambi P; 3Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  • Niyigena EB; 4Independent TB Consultant, Leuven, Belgium.
  • Dusabe T; 5Tuberculosis and Other Respiratory Diseases Division, Institute of HIV/AIDS Disease Prevention and Control, Rwanda Biomedical Centre, Kigali, Rwanda.
  • Habimana YM; 1National Reference Laboratory Division, Department of Biomedical Services, Rwanda Biomedical Centre, Kigali, Rwanda.
  • Ushizimpumu B; 6MDR-TB Clinic, Kabutare Hospital, Huye, Rwanda.
  • Mulders W; 5Tuberculosis and Other Respiratory Diseases Division, Institute of HIV/AIDS Disease Prevention and Control, Rwanda Biomedical Centre, Kigali, Rwanda.
  • Decroo T; 1National Reference Laboratory Division, Department of Biomedical Services, Rwanda Biomedical Centre, Kigali, Rwanda.
  • Affolabi D; 2Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Supply P; 7Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • de Jong BC; 8Research Foundation Flanders, Brussels, Belgium.
  • Rigouts L; 9Laboratoire de Référence des Mycobactéries, Cotonou, Benin.
Am J Trop Med Hyg ; 103(4): 1443-1446, 2020 10.
Article in En | MEDLINE | ID: mdl-32618257
ABSTRACT
We report a case of acquired fluoroquinolone (FQ) resistance under short-course multidrug-resistant tuberculosis (MDR-TB) treatment. The patient was managed at Kabutare hospital, one of the two specialized MDR-TB clinics in Rwanda. A low dose of moxifloxacin was used in the first three critical months. Acquired resistance was identified at the ninth month of treatment, 3 months after stopping kanamycin in a strain initially susceptible only to FQs, kanamycin, and clofazimine. Fluoroquinolone resistance was detected in the same month by deep sequencing as routinely used second-line line probe assay and phenotypic drug susceptibility testing. High-dose FQ, preferably gatifloxacin, should be used to maximize effectiveness.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Multidrug-Resistant / Fluoroquinolones / Mycobacterium tuberculosis Type of study: Prognostic_studies Limits: Female / Humans / Middle aged Country/Region as subject: Africa Language: En Journal: Am J Trop Med Hyg Year: 2020 Type: Article Affiliation country: Rwanda
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Multidrug-Resistant / Fluoroquinolones / Mycobacterium tuberculosis Type of study: Prognostic_studies Limits: Female / Humans / Middle aged Country/Region as subject: Africa Language: En Journal: Am J Trop Med Hyg Year: 2020 Type: Article Affiliation country: Rwanda