Case Report: Dynamics of Acquired Fluoroquinolone Resistance under Standardized Short-Course Treatment of Multidrug-Resistant Tuberculosis.
Am J Trop Med Hyg
; 103(4): 1443-1446, 2020 10.
Article
in En
| MEDLINE
| ID: mdl-32618257
ABSTRACT
We report a case of acquired fluoroquinolone (FQ) resistance under short-course multidrug-resistant tuberculosis (MDR-TB) treatment. The patient was managed at Kabutare hospital, one of the two specialized MDR-TB clinics in Rwanda. A low dose of moxifloxacin was used in the first three critical months. Acquired resistance was identified at the ninth month of treatment, 3 months after stopping kanamycin in a strain initially susceptible only to FQs, kanamycin, and clofazimine. Fluoroquinolone resistance was detected in the same month by deep sequencing as routinely used second-line line probe assay and phenotypic drug susceptibility testing. High-dose FQ, preferably gatifloxacin, should be used to maximize effectiveness.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis, Multidrug-Resistant
/
Fluoroquinolones
/
Mycobacterium tuberculosis
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
/
Middle aged
Country/Region as subject:
Africa
Language:
En
Journal:
Am J Trop Med Hyg
Year:
2020
Type:
Article
Affiliation country:
Rwanda