KD025 Shifts Pulmonary Endothelial Cell Bioenergetics and Decreases Baseline Lung Permeability.

Lee, Ji Young; Stevens, Reece P; Kash, Mary; Zhou, Chun; Koloteva, Anna; Renema, Phoibe; Paudel, Sunita S; Stevens, Troy

Lee, Ji Young; Stevens, Reece P; Kash, Mary; Zhou, Chun; Koloteva, Anna; Renema, Phoibe; Paudel, Sunita S; Stevens, Troy.

Affiliation

Lee JY; Department of Physiology and Cell Biology.
Stevens RP; Department of Internal Medicine.
Kash M; Division of Pulmonary and Critical Care Medicine.
Zhou C; Center for Lung Biology.
Koloteva A; College of Medicine, and.
Renema P; University of South Alabama, Mobile, Alabama.
Paudel SS; Department of Physiology and Cell Biology.
Stevens T; Center for Lung Biology.

Am J Respir Cell Mol Biol ; 63(4): 519-530, 2020 10.

Article in En | MEDLINE | ID: mdl-32628869

Subject(s)

Capillary Permeability/drug effects; Endothelial Cells/drug effects; Endothelium, Vascular/drug effects; Energy Metabolism/drug effects; Heterocyclic Compounds, 4 or More Rings/pharmacology; Lung/drug effects; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology; Adenosine Triphosphate/metabolism; Animals; Annexin A5/metabolism; Cell Movement/drug effects; Deoxyglucose/metabolism; Endothelial Cells/metabolism; Endothelium, Vascular/metabolism; Glycolysis/drug effects; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase/metabolism; Lung/metabolism; Male; Oxidative Phosphorylation/drug effects; Propidium/pharmacology; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Signal Transduction/drug effects; rho-Associated Kinases/metabolism

Key words

anion exchanger 2; bleomycin; caspase-3; hypoxia; rho kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capillary Permeability / Endothelium, Vascular / Endothelial Cells / Energy Metabolism / Heterocyclic Compounds, 4 or More Rings / Lung Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article

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