Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state.

Bu, Wenting; Levitskaya, Zarina; Loh, Zhi Yang; Jin, Shengyang; Basu, Shibom; Ero, Rya; Yan, Xinfu; Wang, Meitian; Ngan, So Fong Cam; Sze, Siu Kwan; Tan, Suet-Mien; Gao, Yong-Gui

Bu, Wenting; Levitskaya, Zarina; Loh, Zhi Yang; Jin, Shengyang; Basu, Shibom; Ero, Rya; Yan, Xinfu; Wang, Meitian; Ngan, So Fong Cam; Sze, Siu Kwan; Tan, Suet-Mien; Gao, Yong-Gui.

Affiliation

Bu W; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Levitskaya Z; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Loh ZY; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Jin S; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Basu S; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore.
Ero R; Swiss Light Source, Paul Scherrer Institute, Villigen, Switzerland.
Yan X; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Wang M; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Ngan SFC; Swiss Light Source, Paul Scherrer Institute, Villigen, Switzerland.
Sze SK; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Tan SM; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Gao YG; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

PLoS Biol ; 18(7): e3000755, 2020 07.

Article in En | MEDLINE | ID: mdl-32644996

Subject(s)

Membrane Proteins/antagonists & inhibitors; Membrane Proteins/chemistry; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/chemistry; Protein Multimerization; Cell Movement; Humans; Integrins/metabolism; K562 Cells; Membrane Proteins/metabolism; Models, Molecular; Neoplasm Proteins/metabolism; Protein Binding; Protein Domains; Structural Homology, Protein; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Multimerization / Membrane Proteins / Neoplasm Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: Singapore

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