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The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.
Biscans, Annabelle; Caiazzi, Jillian; Davis, Sarah; McHugh, Nicholas; Sousa, Jacquelyn; Khvorova, Anastasia.
Affiliation
  • Biscans A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA.
  • Caiazzi J; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01604, USA.
  • Davis S; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA.
  • McHugh N; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01604, USA.
  • Sousa J; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA.
  • Khvorova A; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01604, USA.
Nucleic Acids Res ; 48(14): 7665-7680, 2020 08 20.
Article in En | MEDLINE | ID: mdl-32672813
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Small Interfering / Phosphorothioate Oligonucleotides Limits: Animals Language: En Journal: Nucleic Acids Res Year: 2020 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Small Interfering / Phosphorothioate Oligonucleotides Limits: Animals Language: En Journal: Nucleic Acids Res Year: 2020 Type: Article Affiliation country: United States