Cation channel conductance and pH gating of the innate immunity factor APOL1 are governed by pore-lining residues within the C-terminal domain.
J Biol Chem
; 295(38): 13138-13149, 2020 09 18.
Article
in En
| MEDLINE
| ID: mdl-32727852
Key words
APOL1; APOL1-associated nephropathy; Trypanosoma brucei; apolipoprotein; cytolysis; electrophysiology; focal-segmental glomerulosclerosis (FSGS); glomerulosclerosis; high-density lipoprotein (HDL); human African trypanosomiasis (HAT); innate immunity; ion channel; kidney; kidney disease; lipid bilayer; lipoprotein; nonselective cation channel; pH-dependent membrane insertion; pH-gated cation channel; planar lipid bilayers; trypanosome lytic factor (TLF)
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apolipoprotein L1
/
Immunity, Innate
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Biol Chem
Year:
2020
Type:
Article
Affiliation country:
United States