Relevance of the CXCR4/CXCR7-CXCL12 axis and its effect in pathophysiological conditions.

Huynh, Christine; Dingemanse, Jasper; Meyer Zu Schwabedissen, Henriette E; Sidharta, Patricia N

Huynh, Christine; Dingemanse, Jasper; Meyer Zu Schwabedissen, Henriette E; Sidharta, Patricia N.

Affiliation

Huynh C; Idorsia Pharmaceuticals Ltd, Department of Clinical Pharmacology, Hegenheimermattweg 91, 4123 Allschwil, Switzerland; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Dingemanse J; Idorsia Pharmaceuticals Ltd, Department of Clinical Pharmacology, Hegenheimermattweg 91, 4123 Allschwil, Switzerland.
Meyer Zu Schwabedissen HE; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Sidharta PN; Idorsia Pharmaceuticals Ltd, Department of Clinical Pharmacology, Hegenheimermattweg 91, 4123 Allschwil, Switzerland. Electronic address: patricia.sidharta@idorsia.com.

Pharmacol Res ; 161: 105092, 2020 11.

Article in En | MEDLINE | ID: mdl-32758634

Subject(s)

Central Nervous System Diseases/metabolism; Chemokine CXCL12/metabolism; Neoplasms/metabolism; Receptors, CXCR4/metabolism; Receptors, CXCR/metabolism; Animals; Antineoplastic Agents/therapeutic use; Central Nervous System Agents/therapeutic use; Central Nervous System Diseases/drug therapy; Central Nervous System Diseases/pathology; Central Nervous System Diseases/physiopathology; Humans; Molecular Targeted Therapy; Neoplasms/drug therapy; Neoplasms/pathology; Neoplasms/physiopathology; Signal Transduction

Key words

Balixafortide (PubChem CID: 138752609); Chemokine; Decursin (PubChem CID: 442126); Doxorubicin (PubChem CID: 31703); Enzalutamide (PubChem CID: 15951529); Glioblastoma; LY2510924 (PubChem CID: 129010506); Mafosfamid (PubChem CID: 104746); Motixafortide (PubChem CID: 91865076); Multiple sclerosis; Myocardial infarction; Olaptesed pegol (PubChem CID: 86278354); Plerixafor (PubChem CID: 65015); Prostate carcinoma; Renal cell carcinoma; Ulocuplumab (PubChem SID: 381127169)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Central Nervous System Diseases / Receptors, CXCR4 / Chemokine CXCL12 / Receptors, CXCR / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2020 Type: Article Affiliation country: Switzerland

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