In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study.

Liu, Fangfei; Fan, Lampson M; Michael, Nicholas; Li, Jian-Mei

Liu, Fangfei; Fan, Lampson M; Michael, Nicholas; Li, Jian-Mei.

Affiliation

Liu F; School of Biological Sciences, University of Reading, Reading, UK.
Fan LM; The Royal Wolverhampton NHS Trust, Wolverhampton, UK.
Michael N; Chemical Analysis Facility, University of Reading, Reading, UK.
Li JM; School of Biological Sciences, University of Reading, Reading, UK.

Pharmacol Res Perspect ; 8(4): e00635, 2020 08.

Article in En | MEDLINE | ID: mdl-32761799

Subject(s)

Acetophenones/pharmacology; Antioxidants/pharmacology; Oxidative Stress/drug effects; Reactive Oxygen Species/metabolism; Acetophenones/pharmacokinetics; Aging/drug effects; Animals; Antioxidants/pharmacokinetics; Blood-Brain Barrier/metabolism; Computer Simulation; Diet, High-Fat; Disease Models, Animal; Half-Life; Male; Mice; Mice, Inbred C57BL; Obesity/drug therapy; Tissue Distribution

Key words

NADPH oxidase; PKPD; apocynin; in vivo; obesity; reactive oxygen species

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetophenones / Reactive Oxygen Species / Oxidative Stress / Antioxidants Limits: Animals Language: En Journal: Pharmacol Res Perspect Year: 2020 Type: Article Affiliation country: United kingdom

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