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IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
Zhou, Hao; Wang, Han; Yu, Minjia; Schugar, Rebecca C; Qian, Wen; Tang, Fangqiang; Liu, Weiwei; Yang, Hui; McDowell, Ruth E; Zhao, Junjie; Gao, Ji; Dongre, Ashok; Carman, Julie A; Yin, Mei; Drazba, Judith A; Dent, Robert; Hine, Christopher; Chen, Yeong-Renn; Smith, Jonathan D; Fox, Paul L; Brown, J Mark; Li, Xiaoxia.
Affiliation
  • Zhou H; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Wang H; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Yu M; School of Life Sciences, Lanzhou University, Lanzhou, China.
  • Schugar RC; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Qian W; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA, USA.
  • Tang F; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Liu W; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Yang H; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • McDowell RE; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Zhao J; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Gao J; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Dongre A; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Carman JA; Discovery Biology, Bristol Myers Squibb, Princeton, NJ, USA.
  • Yin M; Discovery Biology, Bristol Myers Squibb, Princeton, NJ, USA.
  • Drazba JA; Discovery Biology, Bristol Myers Squibb, Princeton, NJ, USA.
  • Dent R; Immunology Discovery, Janssen Research and Development, Spring House, PA, USA.
  • Hine C; Imaging Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Chen YR; Imaging Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Smith JD; University of Ottawa and Ottawa Hospital, Ottawa, Ontario, Canada.
  • Fox PL; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Brown JM; Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.
  • Li X; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Nat Immunol ; 21(10): 1219-1231, 2020 10.
Article in En | MEDLINE | ID: mdl-32778760
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-1 / Adipocytes / Mitochondrial Membranes / Interleukin-1 Receptor-Associated Kinases / Inflammation / Obesity Limits: Animals / Humans / Male Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-1 / Adipocytes / Mitochondrial Membranes / Interleukin-1 Receptor-Associated Kinases / Inflammation / Obesity Limits: Animals / Humans / Male Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: United States