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2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis.
Codony, Sandra; Pujol, Eugènia; Pizarro, Javier; Feixas, Ferran; Valverde, Elena; Loza, M Isabel; Brea, José M; Saez, Elena; Oyarzabal, Julen; Pineda-Lucena, Antonio; Pérez, Belén; Pérez, Concepción; Rodríguez-Franco, María Isabel; Leiva, Rosana; Osuna, Sílvia; Morisseau, Christophe; Hammock, Bruce D; Vázquez-Carrera, Manuel; Vázquez, Santiago.
Affiliation
  • Codony S; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
  • Pujol E; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
  • Pizarro J; Pharmacology, Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
  • Feixas F; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Valverde E; Pediatric Research Institute-Hospital Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain.
  • Loza MI; CompBioLab Group, Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, C/ Maria Aurèlia Capmany 69, 17003 Girona, Spain.
  • Brea JM; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
  • Saez E; Drug Screening Platform/Biofarma Research Group, CIMUS Research Center, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.
  • Oyarzabal J; Drug Screening Platform/Biofarma Research Group, CIMUS Research Center, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.
  • Pineda-Lucena A; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.
  • Pérez B; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.
  • Pérez C; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.
  • Rodríguez-Franco MI; Department of Pharmacology, Therapeutics and Toxicology, Institute of Neurosciences, Autonomous University of Barcelona, Bellaterra, 08193 Barcelona, Spain.
  • Leiva R; Institute of Medicinal Chemistry, Spanish National Research Council (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.
  • Osuna S; Institute of Medicinal Chemistry, Spanish National Research Council (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.
  • Morisseau C; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Universitat de Barcelona, 08028 Barcelona, Spain.
  • Hammock BD; CompBioLab Group, Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, C/ Maria Aurèlia Capmany 69, 17003 Girona, Spain.
  • Vázquez-Carrera M; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.
  • Vázquez S; Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, Davis, California 95616, United States.
J Med Chem ; 63(17): 9237-9257, 2020 09 10.
Article in En | MEDLINE | ID: mdl-32787085
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatitis / Urea / Enzyme Inhibitors / Epoxide Hydrolases Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Type: Article Affiliation country: Spain
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatitis / Urea / Enzyme Inhibitors / Epoxide Hydrolases Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Type: Article Affiliation country: Spain