Recent Advances in Biomaterials for the Treatment of Bone Defects.
Organogenesis
; 16(4): 113-125, 2020 10 01.
Article
in En
| MEDLINE
| ID: mdl-32799735
ABSTRACT
Bone defects or fractures generally heal in the absence of major interventions due to the high regenerative capacity of bone tissue. However, in situations of severe/large bone defects, these orchestrated regeneration mechanisms are impaired. With advances in modern medicine, natural and synthetic bio-scaffolds from bioceramics and polymers that support bone growth have emerged and gained intense research interest. In particular, scaffolds that recapitulate the molecular cues of extracellular signals, particularly growth factors, offer potential as therapeutic bone biomaterials. The current challenges for these therapies include the ability to engineer materials that mimic the biological and mechanical properties of the real bone tissue matrix, whilst simultaneously supporting bone vascularization. In this review, we discuss the very recent innovative strategies in bone biomaterial technology, including those of endogenous biomaterials and cell/drug delivery systems that promote bone regeneration. We present our understanding of their current value and efficacy, and the future perspectives for bone regenerative medicine.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biocompatible Materials
/
Bone and Bones
/
Bone Regeneration
/
Tissue Engineering
/
Tissue Scaffolds
Limits:
Humans
Language:
En
Journal:
Organogenesis
Year:
2020
Type:
Article
Affiliation country:
China