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Two new sesquiterpenes from the stems of Tripterygium wilfordii.
Xiu, Meng-Xue; Meng, Xiao; Li, Na; Wang, Dong; Xiong, Da-Xi; Jiang, Yi-Yu; Sun, Ya-Nan; Chen, Li; Cui, Long.
Affiliation
  • Xiu MX; College of Pharmacy, Beihua University, Jilin 132013, China.
  • Meng X; College of Pharmacy, Beihua University, Jilin 132013, China.
  • Li N; Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Wang D; College of Pharmacy, Beihua University, Jilin 132013, China.
  • Xiong DX; College of Pharmacy, Beihua University, Jilin 132013, China.
  • Jiang YY; College of Pharmacy, Beihua University, Jilin 132013, China.
  • Sun YN; College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
  • Chen L; Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Cui L; College of Pharmacy, Beihua University, Jilin 132013, China.
J Asian Nat Prod Res ; 23(5): 423-428, 2021 May.
Article in En | MEDLINE | ID: mdl-32844667
ABSTRACT
Two new ß-dihydroagarofuran-type sesquiterpenes 1ß,2α,6α,8ß,15- pentaacetoxy- 9α-benzoyloxy- ß-dihydroagarofuran (1) and 1ß,2ß,6α,15-tetraacetoxy-9ß-benzoyloxy- ß-dihydroagarofuran (2), together with five known abietane diterpenoids (3-7) were isolated from ethyl acetate extract of stems of Tripterygium wilfordii. Their structures were elucidated on the basis of detailed spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against A549, HOS and MCF-7. Among them, compounds 4 and 5 exhibited manifest inhibition on A549, HOS and MCF-7 cancer cell lines.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Drugs, Chinese Herbal Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Drugs, Chinese Herbal Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2021 Type: Article Affiliation country: China