Ivabradine-Induced Torsade de Pointes in Patients with Heart Failure Reduced Ejection Fraction.
Int Heart J
; 61(5): 1044-1048, 2020 Sep 29.
Article
in En
| MEDLINE
| ID: mdl-32921663
ABSTRACT
Ivabradine is a selective inhibitor of the sinoatrial node "funny" current, prolonging the slow diastolic depolarization. As it has the ability to block the heart rate selectively, it is more effective at a faster heart rate. It is recommended for the treatment of heart failure reduced ejection fraction in the presence of beta-blocker therapy for the further reduction of the heart rate. However, previous reports have shown the association of Torsade de pointes (TdP) with concurrent use of ivabradine and drugs resulting in QT prolongation or blockage of the metabolic breakdown of ivabradine. In this article, we report two cases of patients with heart failure reduced ejection fraction who developed TdP after ivabradine use. Our report highlights the need to exercise caution with the administration of ivabradine in the presence of a reduced repolarization reserve, such as QT prolongation or metabolic insufficiency.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Agents
/
Torsades de Pointes
/
Ivabradine
/
Heart Failure
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int Heart J
Journal subject:
CARDIOLOGIA
Year:
2020
Type:
Article