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Quinolizidine alkaloids from the roots of Sophora flavescens.
Li, Jian-Chun; Zhang, Zhi-Jun; Liu, Dan; Jiang, Ming-Yan; Li, Rong-Tao; Li, Hong-Mei.
Affiliation
  • Li JC; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
  • Zhang ZJ; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
  • Liu D; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
  • Jiang MY; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
  • Li RT; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
  • Li HM; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
Nat Prod Res ; 36(7): 1781-1788, 2022 Apr.
Article in En | MEDLINE | ID: mdl-32924588
ABSTRACT
Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1), were isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)-Δ7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported for the first time. In addition, (+)-sophoranol (4) exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 22.14 µM, while lupanine (17) was found to inhibit the growth of human glioma stem cells GSC-3# at 20 µg/mL.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sophora / Alkaloids / Quinolizidines Limits: Humans Language: En Journal: Nat Prod Res Year: 2022 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sophora / Alkaloids / Quinolizidines Limits: Humans Language: En Journal: Nat Prod Res Year: 2022 Type: Article