Quinolizidine alkaloids from the roots of Sophora flavescens.
Nat Prod Res
; 36(7): 1781-1788, 2022 Apr.
Article
in En
| MEDLINE
| ID: mdl-32924588
ABSTRACT
Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1), were isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)-Δ7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported for the first time. In addition, (+)-sophoranol (4) exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 22.14 µM, while lupanine (17) was found to inhibit the growth of human glioma stem cells GSC-3# at 20 µg/mL.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sophora
/
Alkaloids
/
Quinolizidines
Limits:
Humans
Language:
En
Journal:
Nat Prod Res
Year:
2022
Type:
Article