5-Hydroxytryptamine (5-HT) Positively Regulates Pigmentation via Inducing Melanoblast Specification and Melanin Synthesis in Zebrafish Embryos.

Liu, Li; Zhong, Min; Dong, Jing; Chen, Minghan; Shang, Jing; Yue, Yunyun

Liu, Li; Zhong, Min; Dong, Jing; Chen, Minghan; Shang, Jing; Yue, Yunyun.

Affiliation

Liu L; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Zhong M; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Dong J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Chen M; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Shang J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Yue Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.

Biomolecules ; 10(9)2020 09 19.

Article in En | MEDLINE | ID: mdl-32961761

Subject(s)

Melanins/biosynthesis; Melanocytes/drug effects; Pigmentation/drug effects; Serotonin/pharmacology; Stem Cells/drug effects; Zebrafish/genetics; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/drug effects; Embryo, Nonmammalian/metabolism; Gene Expression Regulation, Developmental/drug effects; Larva/drug effects; Larva/metabolism; Larva/physiology; Melanocytes/cytology; Melanocytes/metabolism; Microphthalmia-Associated Transcription Factor/genetics; Microphthalmia-Associated Transcription Factor/metabolism; Neural Crest/cytology; Neural Crest/drug effects; Neural Crest/metabolism; Pigmentation/genetics; Regeneration/drug effects; Regeneration/genetics; Stem Cells/cytology; Stem Cells/metabolism; Zebrafish/embryology; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Key words

5-hydroxytryptamine; melanocytes differentiation; melanocytes regeneration; protein kinase A signaling; zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Zebrafish / Pigmentation / Serotonin / Melanins / Melanocytes Limits: Animals Language: En Journal: Biomolecules Year: 2020 Type: Article Affiliation country: China

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