Phase 1 study of pomalidomide in children with recurrent, refractory, and progressive central nervous system tumors: A Pediatric Brain Tumor Consortium trial.

Fangusaro, Jason; Mitchell, Duane A; Kocak, Mehmet; Robinson, Giles W; Baxter, Patricia Ann; Hwang, Eugene I; Huang, Jianping; Onar-Thomas, Arzu; Dunkel, Ira J; Fouladi, Maryam; Warren, Katherine E

Fangusaro, Jason; Mitchell, Duane A; Kocak, Mehmet; Robinson, Giles W; Baxter, Patricia Ann; Hwang, Eugene I; Huang, Jianping; Onar-Thomas, Arzu; Dunkel, Ira J; Fouladi, Maryam; Warren, Katherine E.

Affiliation

Fangusaro J; Children's Healthcare of Atlanta and Emory University Medical School, Atlanta, Georgia.
Mitchell DA; Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida Brain Tumor Immunotherapy Program, Gainesville, Florida.
Kocak M; University of Tennessee Health Science Center, Memphis, Tennessee.
Robinson GW; St Jude Children's Research Hospital, Memphis, Tennessee.
Baxter PA; Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas.
Hwang EI; Children's National Health System, Washington, District of Columbia.
Huang J; Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida Brain Tumor Immunotherapy Program, Gainesville, Florida.
Onar-Thomas A; St Jude Children's Research Hospital, Memphis, Tennessee.
Dunkel IJ; Memorial Sloan Kettering Cancer Center, New York, New York.
Fouladi M; Nationwide Children's Hospital, Columbus, Ohio.
Warren KE; Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

Pediatr Blood Cancer ; 68(2): e28756, 2021 02.

Article in En | MEDLINE | ID: mdl-33025730

Subject(s)

Angiogenesis Inhibitors/therapeutic use; Antineoplastic Agents/therapeutic use; Central Nervous System Neoplasms/drug therapy; Thalidomide/analogs & derivatives; Adolescent; Angiogenesis Inhibitors/pharmacokinetics; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacokinetics; Central Nervous System Neoplasms/mortality; Central Nervous System Neoplasms/pathology; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Immunomodulation/drug effects; Male; Thalidomide/pharmacokinetics; Thalidomide/therapeutic use; Young Adult

Key words

IMiD agent; brain tumor; central nervous system tumor; pediatric; pomalidomide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thalidomide / Central Nervous System Neoplasms / Angiogenesis Inhibitors / Antineoplastic Agents Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2021 Type: Article Affiliation country: Georgia

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