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Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study.
Gounder, Mrinal; Schöffski, Patrick; Jones, Robin L; Agulnik, Mark; Cote, Gregory M; Villalobos, Victor M; Attia, Steven; Chugh, Rashmi; Chen, Tom Wei-Wu; Jahan, Thierry; Loggers, Elizabeth T; Gupta, Abha; Italiano, Antoine; Demetri, George D; Ratan, Ravin; Davis, Lara E; Mir, Olivier; Dileo, Palma; Van Tine, Brian A; Pressey, Joseph G; Lingaraj, Trupti; Rajarethinam, Anand; Sierra, Laura; Agarwal, Shefali; Stacchiotti, Silvia.
Affiliation
  • Gounder M; Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA. Electronic address: gounderm@mskcc.org.
  • Schöffski P; Department of General Medical Oncology, and Laboratory of Experimental Oncology, University Hospitals Leuven, KU Leuven, Leuven Cancer Institute, Leuven, Belgium.
  • Jones RL; Royal Marsden Hospital and Institute of Cancer Research, London, UK.
  • Agulnik M; Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA.
  • Cote GM; Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Villalobos VM; Anschutz Medical Campus, University of Colorado Denver, Aurora, CO, USA; Janssen Pharmaceuticals, Spring House, PA, USA.
  • Attia S; Mayo Clinic, Jacksonville, FL, USA.
  • Chugh R; University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
  • Chen TW; National Taiwan University Hospital and Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Jahan T; University of California San Francisco, San Francisco, CA, USA.
  • Loggers ET; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Gupta A; The Hospital for Sick Children and Princess Margaret Cancer Center, Toronto, ON, Canada.
  • Italiano A; Institut Bergonie and University of Bordeaux, Bordeaux, France.
  • Demetri GD; Dana Farber Cancer Institute and Ludwig Center at Harvard Medical School, Boston, MA, USA.
  • Ratan R; MD Anderson Cancer Center, Houston, TX, USA.
  • Davis LE; Oregon Health & Science University, Knight Cancer Institute, Portland, OR, USA.
  • Mir O; Gustave Roussy Cancer Institute, Paris, France.
  • Dileo P; University College London Hospitals NHS Foundation Trust, London, UK.
  • Van Tine BA; School of Medicine, Washington University in St Louis, St Louis, MO, USA.
  • Pressey JG; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Lingaraj T; Epizyme, Cambridge, MA, USA.
  • Rajarethinam A; Epizyme, Cambridge, MA, USA.
  • Sierra L; Epizyme, Cambridge, MA, USA; Bristol Myers Squibb, Cambridge, MA, USA.
  • Agarwal S; Epizyme, Cambridge, MA, USA.
  • Stacchiotti S; Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Lancet Oncol ; 21(11): 1423-1432, 2020 11.
Article in En | MEDLINE | ID: mdl-33035459
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Sarcoma / Benzamides / SMARCB1 Protein Type of study: Clinical_trials Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Lancet Oncol Journal subject: NEOPLASIAS Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Sarcoma / Benzamides / SMARCB1 Protein Type of study: Clinical_trials Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Lancet Oncol Journal subject: NEOPLASIAS Year: 2020 Type: Article