Regulatory T Cells Maintain Selective Access to IL-2 and Immune Homeostasis despite Substantially Reduced CD25 Function.

Hayes, Erika T; Hagan, Cassidy E; Khoryati, Liliane; Gavin, Marc A; Campbell, Daniel J

Hayes, Erika T; Hagan, Cassidy E; Khoryati, Liliane; Gavin, Marc A; Campbell, Daniel J.

Affiliation

Hayes ET; Immunology Program, Benaroya Research Institute, Seattle, WA 98101; and.
Hagan CE; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.
Khoryati L; Immunology Program, Benaroya Research Institute, Seattle, WA 98101; and.
Gavin MA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.
Campbell DJ; Immunology Program, Benaroya Research Institute, Seattle, WA 98101; and.

J Immunol ; 205(10): 2667-2678, 2020 11 15.

Article in En | MEDLINE | ID: mdl-33055282

Subject(s)

Antibodies, Monoclonal/pharmacology; Interleukin-2 Receptor alpha Subunit/antagonists & inhibitors; Interleukin-2/metabolism; T-Lymphocytes, Regulatory/immunology; Animals; Antibodies, Monoclonal/therapeutic use; Autoimmune Diseases/drug therapy; Autoimmune Diseases/immunology; Cell Proliferation; Graft Rejection/immunology; Graft Rejection/prevention & control; Humans; Immune Tolerance/drug effects; Interleukin-2 Receptor alpha Subunit/metabolism; Mice; Models, Animal; Signal Transduction/drug effects; Signal Transduction/immunology; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-2 / T-Lymphocytes, Regulatory / Interleukin-2 Receptor alpha Subunit / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2020 Type: Article

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