STK4 Deficiency Impairs Innate Immunity and Interferon Production Through Negative Regulation of TBK1-IRF3 Signaling.

Jørgensen, Sofie E; Al-Mousawi, Ali; Assing, Kristian; Hartling, Ulla; Grosen, Dorthe; Fisker, Niels; Nielsen, Christian; Jakobsen, Marianne A; Mogensen, Trine H

Jørgensen, Sofie E; Al-Mousawi, Ali; Assing, Kristian; Hartling, Ulla; Grosen, Dorthe; Fisker, Niels; Nielsen, Christian; Jakobsen, Marianne A; Mogensen, Trine H.

Affiliation

Jørgensen SE; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Al-Mousawi A; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Assing K; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Hartling U; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Grosen D; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
Fisker N; Department of Pediatrics, Odense University Hospital, Odense, Denmark.
Nielsen C; Department of Pediatrics, Odense University Hospital, Odense, Denmark.
Jakobsen MA; Department of Pediatrics, Odense University Hospital, Odense, Denmark.
Mogensen TH; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

J Clin Immunol ; 41(1): 109-124, 2021 01.

Article in En | MEDLINE | ID: mdl-33078349

Subject(s)

Immunity, Innate/genetics; Interferon Regulatory Factor-3/metabolism; Interferons/biosynthesis; Intracellular Signaling Peptides and Proteins/deficiency; Protein Serine-Threonine Kinases/deficiency; Protein Serine-Threonine Kinases/metabolism; Signal Transduction; Adaptive Immunity; Alleles; Autophagy; Cell Differentiation; Cell Proliferation; Cell Survival/genetics; Cytokines/biosynthesis; Female; Genotype; Hippo Signaling Pathway; Humans; Immunocompromised Host; Immunophenotyping; Infections/etiology; Infections/metabolism; Lymphocyte Activation; Macrophages/immunology; Macrophages/metabolism; Male; Mutation; Neutrophils/immunology; Neutrophils/metabolism; Pedigree; Phenotype; T-Lymphocytes/immunology; T-Lymphocytes/metabolism

Key words

Autophagy; IRF3; Interferon; MST1; Oxidative burst; STK4; T cell lymphopenia; TBK1; Tregs

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Interferons / Protein Serine-Threonine Kinases / Intracellular Signaling Peptides and Proteins / Interferon Regulatory Factor-3 / Immunity, Innate Type of study: Etiology_studies Limits: Female / Humans / Male Language: En Journal: J Clin Immunol Year: 2021 Type: Article Affiliation country: Denmark

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