Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors.

Mohamed, Mamdouh F A; Marzouk, Adel A; Nafady, Ayman; El-Gamal, Dalia A; Allam, Rasha M; Abuo-Rahma, Gamal El-Din A; El Subbagh, Hussein I; Moustafa, Amr H

Mohamed, Mamdouh F A; Marzouk, Adel A; Nafady, Ayman; El-Gamal, Dalia A; Allam, Rasha M; Abuo-Rahma, Gamal El-Din A; El Subbagh, Hussein I; Moustafa, Amr H.

Affiliation

Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt. Electronic address: mamdouh.fawzi@pharm.sohag.edu.eg.
Marzouk AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt.
Nafady A; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
El-Gamal DA; Histology Department, Faculty of Medicine, Assiut University, 71526 Assiut, Egypt.
Allam RM; Pharmacology Department, National Research Centre, Giza 11865, Egypt.
Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
El Subbagh HI; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt.
Moustafa AH; Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt.

Bioorg Chem ; 105: 104439, 2020 12.

Article in En | MEDLINE | ID: mdl-33161252

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis; Dinoprostone/antagonists & inhibitors; Enzyme Inhibitors/chemical synthesis; Indomethacin/chemistry; Nitric Oxide Synthase Type II/antagonists & inhibitors; Oxadiazoles/chemical synthesis; Animals; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics; Carrageenan/chemistry; Celecoxib/metabolism; Dose-Response Relationship, Drug; Edema/drug therapy; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/pharmacokinetics; Humans; Lipopolysaccharides/chemistry; Male; Mice; Molecular Docking Simulation; Molecular Structure; Nitric Oxide/metabolism; Oxadiazoles/administration & dosage; Oxadiazoles/pharmacokinetics; Oximes/chemistry; RAW 264.7 Cells; Rats

Key words

Amidoxime; Anti-inflammatory; Indomethacin; NOS inhibitors; Oxadiazole; iNOS

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Dinoprostone / Anti-Inflammatory Agents, Non-Steroidal / Indomethacin / Enzyme Inhibitors / Nitric Oxide Synthase Type II Limits: Animals / Humans / Male Language: En Journal: Bioorg Chem Year: 2020 Type: Article

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