Biological variation of total thyroxine (T4), free T4 and thyroid-stimulating hormone in 11 clinically healthy cats.
J Feline Med Surg
; 23(6): 592-597, 2021 06.
Article
in En
| MEDLINE
| ID: mdl-33174484
ABSTRACT
OBJECTIVES:
The aim of this study was to investigate the biological variation of total thyroxine (T4), free T4 (fT4) and thyroid-stimulating hormone (TSH) in 11 clinically healthy cats aged between 3 and 15 years old, in Sydney, Australia.METHODS:
Blood was collected weekly for up to 6 weeks and serum T4, fT4 and TSH concentrations were analysed using canine-specific reagents. Restricted maximum likelihood was used to estimate within-subject, between-subject and analytical variance components, which were recorded in terms of the related coefficients of variation. The index of individuality and reference change values were then calculated for each analyte.RESULTS:
T4 and TSH had intermediate individuality, indicating both subject-based and population-based reference intervals (RIs) could be used, with the knowledge that population-based RIs are suboptimally sensitive. fT4 had high individuality, indicating subject-based RIs are more appropriate than population-based RIs. CONCLUSIONS AND RELEVANCE This study has demonstrated that subject-based RIs could be more sensitive than population-based RIs for the diagnosis of thyroid dysfunction in cats.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroxine
/
Thyrotropin
Limits:
Animals
Language:
En
Journal:
J Feline Med Surg
Journal subject:
MEDICINA VETERINARIA
Year:
2021
Type:
Article
Affiliation country:
Australia